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Recommendations for preclinical research in hemorrhagic transformation
Susan C Fagan1, Paul A Lapchak, David S Liebeskind
1Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA ; Charlie Norwood VA Medical Center, Augusta, GA ; Department of Neurology, Medical College of Georgia, Augusta, GA.
Translational Stroke Research
|June 5, 2013
Summary
Hemorrhagic transformation (HT) is a major complication after ischemic stroke, often linked to reperfusion therapy. This review outlines research models, clinical factors, and variables influencing HT quantitation, offering recommendations for future preclinical studies.
Area of Science:
- Neurology
- Stroke Research
- Hemorrhagic Transformation
Background:
- Hemorrhagic transformation (HT) is a critical complication following ischemic stroke.
- It significantly contributes to mortality, particularly with acute reperfusion therapies.
- Existing preclinical stroke models lack standardized research guidelines for HT investigation.
Purpose of the Study:
- To review current preclinical models used for studying hemorrhagic transformation (HT).
- To discuss clinical correlations and experimental variables affecting HT quantitation.
- To provide recommendations for conducting future HT research.
Main Methods:
- Literature review of preclinical models for ischemic stroke and HT.
- Analysis of clinical factors and experimental parameters influencing HT.
- Synthesis of findings to formulate research recommendations.
Main Results:
- Identified diverse preclinical models for investigating HT.
- Highlighted key clinical correlates and experimental variables impacting HT assessment.
- Established a basis for standardized HT research protocols.
Conclusions:
- Standardized methodologies are crucial for advancing HT research.
- Recommendations are provided to improve the design and execution of preclinical HT studies.
- This review aims to guide future research for better understanding and management of HT in ischemic stroke.
