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Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
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Related Experiment Video

Updated: May 10, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

Dynamic combinatorial libraries: from exploring molecular recognition to systems chemistry.

Jianwei Li1, Piotr Nowak, Sijbren Otto

  • 1Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Journal of the American Chemical Society
|June 5, 2013
PubMed
Summary
This summary is machine-generated.

Dynamic combinatorial chemistry (DCC) utilizes interconverting molecules to discover novel structures like self-replicators. This approach, dynamic combinatorial libraries (DCLs), offers new avenues in systems chemistry and molecular machines.

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Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
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Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

Related Experiment Videos

Last Updated: May 10, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

Area of Science:

  • Chemistry
  • Supramolecular Chemistry
  • Systems Chemistry

Background:

  • Dynamic combinatorial chemistry (DCC) involves libraries where members continuously exchange building blocks.
  • Dynamic combinatorial libraries (DCLs) are key for discovering unexpected molecular structures and functions.
  • DCLs enable emergent properties in molecular networks, opening new possibilities in systems chemistry.

Purpose of the Study:

  • To highlight new methodologies in dynamic combinatorial chemistry.
  • To analyze DCLs under thermodynamic control for applications in synthesis and self-assembly.
  • To review extensions of DCC principles to non-equilibrium systems for advanced functionalities.

Main Methods:

  • Exploration of dynamic interconversion of chemical library members.
  • Thermodynamic control of dynamic combinatorial libraries.
  • Application of DCC principles to non-equilibrium systems.

Main Results:

  • Discovery of novel molecules, including interlocked structures and self-replicators.
  • Development of synthetic receptors, catalytic systems, and supramolecular architectures.
  • Demonstration of richer functional behavior in non-equilibrium systems, such as self-replication and molecular machines.

Conclusions:

  • DCLs are powerful tools for molecular discovery and systems chemistry.
  • Thermodynamic control in DCLs yields diverse functional systems.
  • Extending DCC to non-equilibrium systems unlocks advanced molecular functionalities.