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Co-infections with hepatitis B and C viruses in human immunodeficiency virus-infected patients in Morocco

K Rebbani1, A Ouladlahsen, A Bensghir

  • 1Virology Unit, Viral Hepatitis Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|June 5, 2013
PubMed

Insights

This study investigated HIV/hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infections in Morocco. Results show a 10.6% co-infection rate, with specific HBV genotype D and an unusual HCV subtype distribution.

Area of Science:

  • * Infectious Diseases
  • * Hepatology
  • * Virology

Background:

  • * Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) represent significant global public health challenges.
  • * Understanding co-infection patterns is crucial for managing HIV-infected populations and preventing viral hepatitis transmission.

Purpose of the Study:

  • * To determine the prevalence of HBV and HCV infections in HIV-infected patients in Morocco.
  • * To identify the primary circulating HBV and HCV genotypes and subtypes within this cohort.
  • * To compare findings with the general population's viral hepatitis strain distribution.

Main Methods:

  • * Cross-sectional study involving 503 HIV-infected patients in Morocco.
  • * Screening for HBV surface antigen and anti-HCV antibodies.
  • * HBV DNA sequencing for genotyping and HCV sequencing for subtyping.

Main Results:

  • * A 10.6% prevalence of HIV/hepatitis co-infection was observed.
  • * HBV surface antigen positivity was 5.2%, and anti-HCV positivity was 5.4%.
  • * Exclusively HBV genotype D (D1 and D7) was identified, consistent with general population data. HCV isolates showed an unusual subtype distribution: 1a and 3a (23.5% each), 1b and 4a (17.6% each), 1c (11.8%), and 6h (6%).

Conclusions:

  • * HIV/HBV and HIV/HCV co-infections are prevalent in the studied Moroccan HIV-infected population.
  • * HBV strains align with general population data, but HCV subtypes present an atypical distribution requiring further investigation.
  • * These findings highlight the need for targeted screening and management strategies for viral hepatitis in HIV patients in Morocco.

Keywords:
Chronic hepatitisco-infectiongenotypehuman immunodeficiency virusprevalence

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