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Related Concept Videos

Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

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Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
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Communication01:03

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Communication between two animals occurs when one animal transmits an information signal that causes a change in the animal that receives the information. Organisms communicate with one another in a host of different ways. Signals can be auditory, chemical, visual, tactile, or a combination of these. Communication is a critical behavioral adaptation that promotes survival, growth, and reproduction.
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Sharing information, concepts, and emotions to foster mutual understanding is communication. The sender, recipient, and transaction must be considered in this manner. The sender is the person who shares the message, the recipient is the person who receives and understands the message, and the transaction is the method used to deliver the message and the variables that affect the communication's context and surroundings. The nurse-client connection is built on therapeutic communication.
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Facilitated Transport01:19

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The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
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Primary Active Transport01:47

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Related Experiment Video

Updated: Jan 24, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
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Cellular communication via nanoparticle-transporting biovesicles.

Silvia Ferrati1, Kellie I McConnell1, Aaron C Mack1

  • 1Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Avenue, R7-414, Houston, TX 77030, USA.

Nanomedicine (London, England)
|June 5, 2013
PubMed
Summary
This summary is machine-generated.

Endothelial cells transport nanoparticles within vesicles. These cell-derived biovesicles, originating from endosomes or apoptotic cells, facilitate cell-to-cell communication and cargo delivery across tissues.

Keywords:
biovesicleendotheliaexocytosisiron oxidemicrovesiclenanoparticle

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Area of Science:

  • Cell Biology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Endothelial cells regulate transport between blood and tissues.
  • Cellular communication relies on the exchange of biological signals.
  • Nanoparticles are investigated for targeted delivery applications.

Purpose of the Study:

  • To investigate nanoparticle transport across endothelial cells using biovesicles.
  • To characterize the origin and content of nanoparticle-laden biovesicles.
  • To evaluate the role of biovesicles in cell-to-cell communication.

Main Methods:

  • Characterization of cell-free endothelial-derived biovesicles using electron microscopy.
  • Confocal microscopy to identify organelle-specific proteins and monitor biovesicle uptake.
  • Analysis of biovesicles containing low-density and high-density polyethyleneimine nanoparticles.

Main Results:

  • Low-density nanoparticle biovesicles showed endosomal origins (multivesicular bodies, lysosomes, autophagosomes).
  • High-density nanoparticles induced biovesicles linked to apoptotic cell breakdown.
  • LAMP-1-positive biovesicles were internalized by recipient cells, regardless of origin.

Conclusions:

  • Cellular biovesicles serve as a key mechanism for cell-to-cell communication.
  • Biovesicles can mediate the transport of cellular signals and potentially nanoparticles.
  • This vesicular transport offers a pathway for local and broadcasted biological messaging.