Related Experiment Video

Updated: May 10, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Neutrophil roles in left ventricular remodeling following myocardial infarction

Yonggang Ma1, Andriy Yabluchanskiy, Merry L Lindsey

  • 1San Antonio Cardiovascular Proteomics Center, San Antonio, TX, USA. yma@umc.edu.

Fibrogenesis & Tissue Repair
|June 5, 2013
PubMed

Insights

Neutrophils, or polymorphonuclear granulocytes (PMNs), are crucial for innate immunity and fighting infections. This review explores their roles in inflammation and immunity, particularly in myocardial infarction.

Area of Science:

  • Immunology
  • Cell Biology
  • Innate Immunity

Background:

  • Polymorphonuclear granulocytes (PMNs), also known as neutrophils, are vital innate immune cells.
  • They defend against pathogens via inflammation, reactive oxygen species, and granule component release.
  • Neutrophil extracellular traps (NETs) represent an additional antimicrobial mechanism.

Purpose of the Study:

  • To review the biology of PMNs, including their characteristics, recruitment, activation, and clearance.
  • To elucidate the function of PMN-derived granule proteins in inflammation and immunity.
  • To focus on the role of PMNs in the context of myocardial infarction (MI).

Main Methods:

  • Literature review of neutrophil biology and function.
  • Analysis of PMN roles in innate immunity and inflammatory processes.
  • Specific examination of PMN involvement in myocardial infarction.

Main Results:

  • PMNs are multifaceted immune cells with diverse antimicrobial and inflammatory functions.
  • PMN-derived granule proteins contribute significantly to both pathogen clearance and inflammatory responses.
  • Neutrophil extracellular traps (NETs) offer a distinct mechanism for pathogen containment.

Conclusions:

  • PMNs are central players in innate immunity and inflammation, with implications extending to conditions like MI.
  • Understanding PMN granule protein functions is key to developing targeted therapies.
  • Future research directions in PMN biology are highlighted.

More Related Videos

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...