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Related Experiment Video

Updated: May 10, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Diagnostic imaging in obesity.

Jürgen Machann¹, Annette Horstmann, Mark Born

¹Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen (Paul Langerhans Institute Tübingen), Tübingen, Germany. juergen.machann@med.uni-tuebingen.de

Best Practice & Research. Clinical Endocrinology & Metabolism

|June 5, 2013

Summary

This summary is machine-generated.

Magnetic resonance imaging (MRI) reveals that obesity is linked to body composition and fat deposits, not just metabolic failure. Advanced imaging techniques like MRI and Positron Emission Tomography (PET) are crucial for understanding obesity and related conditions.

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Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using ¹⁸F-FDG PET/CT

Published on: April 1, 2019

Area of Science:

Medical Imaging
Metabolic Research
Body Composition Analysis

Background:

Obesity is a complex condition influenced by regional body composition and ectopic lipid accumulation.
Magnetic resonance (MR) techniques offer advanced methods for assessing fat deposits and analyzing lipids in organs.
Current diagnostic tools for conditions like hepatic steatosis have limitations.

Purpose of the Study:

To present and discuss whole-body adipose tissue assessment using MR imaging (MRI) and MR spectroscopy.
To explore the role of brain MRI in understanding obesity and food overconsumption.
To evaluate novel sonographic methods for detecting hepatic steatosis and utilizing nuclear medicine for metabolic research.

Main Methods:

Magnetic resonance imaging (MRI) for mapping fat deposits and assessing body composition.
MR spectroscopy for analyzing lipids in various organs.
Sonography, evaluating tissue stiffness, sound absorption, and sound speed for hepatic steatosis detection.
Positron Emission Tomography (PET) for exploring central pathophysiology and adipose tissue activity.

Main Results:

MRI indicates that obesity's metabolic impact depends on regional fat distribution and ectopic lipid accumulation.
Brain MRI serves as a key tool for investigating the neural mechanisms of obesity.
New sonographic approaches show promise for improved hepatic steatosis diagnosis.
PET methods are valuable for studying brown adipose tissue and gut-brain communication in metabolic disorders.

Conclusions:

Body composition and regional fat distribution are critical factors in metabolic health, as revealed by MRI.
Advanced imaging and spectroscopy provide crucial insights into the pathophysiology of obesity and related metabolic conditions.
Innovations in sonography and nuclear medicine are enhancing diagnostic capabilities for conditions like hepatic steatosis and understanding metabolic regulation.