Non-invasively measured aortic wave reflection and pulse pressure amplification are related to the severity of

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Published on: September 27, 2024

Sung Woo Cho1, Byung Kyu Kim, Jeong Hoon Kim

  • 1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.

Journal of Cardiology
|June 5, 2013
PubMed

Insights

Aortic wave reflection and pulse pressure amplification are linked to coronary artery disease severity, especially in patients under 65. These cardiovascular disease risk factors show a stronger association in younger individuals.

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Vascular Physiology

Background:

  • Augmentation index (AIx) and pulse pressure amplification (PPA) are emerging cardiovascular disease risk factors associated with aging.
  • The predictive value of AIx and PPA for coronary artery disease (CAD) risk remains incompletely understood.

Purpose of the Study:

  • To investigate the association between non-invasively measured aortic wave reflection (AWR) and PPA with CAD.
  • To determine if AIx and PPA can predict CAD risk.

Main Methods:

  • Eighty patients undergoing elective coronary angiography were included.
  • Non-invasive measurements of augmentation pressure (AP), AIx, and PPA were performed using radial applanation tonometry.

Main Results:

  • A significant association between CAD extent and AIx/PPA was observed in patients <65 years, but not in those ≥65 years.
  • Multivariate analysis revealed that increased AIx and PPA were significant predictors of 3-vessel disease in patients <65 years.
  • Gensini score for CAD severity correlated with AP, AIx, and PPA in younger patients (<65 years).

Conclusions:

  • Non-invasively measured aortic wave reflection and PPA are associated with CAD severity.
  • This association is particularly pronounced in patients younger than 65 years.
Abstract

Keywords:
Aortic wave reflectionArterial stiffnessCoronary artery diseasePulse pressure amplificationRadial applanation tonometry

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