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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Published on: July 25, 2019

Non-canonical ubiquitylation: mechanisms and consequences

Gary S McDowell1, Anna Philpott

  • 1Department of Oncology, University of Cambridge, Hutchison/Medical Research Council (MRC) Research Centre, Cambridge, UK.

The International Journal of Biochemistry & Cell Biology
|June 5, 2013
PubMed
Summary

Non-canonical ubiquitylation modifies proteins at non-lysine sites, impacting cellular processes. This review explores these unusual modifications and their consequences on protein activity and fate.

Keywords:
ERADHECTHOMOLUMONon-canonical ubiquitylationProtein degradationRINGSCFSUMOSkp-Cullin-F-boxUFDUPSUbUbiquitinUbiquitin ligaseUbiquitinomicsendoplasmic reticulum-associated degradationhighest occupied molecular orbitalhomologous to E6 carboxyl terminuslowest unoccupied molecular orbitalreally Interesting New Genesmall ubiquitin-like modifierubiquitinubiquitin fusion degradationubiquitin proteasome system

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