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Inflammatory Bowel Disease III: Crohn's Disease

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Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
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Published on: August 13, 2015

Interstitial cystitis: another IgG4-related inflammatory disease?

Suzanne Crumley1, Yimin Ge, Haijun Zhou

  • 1Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, TX.

Annals of Diagnostic Pathology
|June 5, 2013
PubMed
Summary

Interstitial cystitis (IC), a bladder condition, may involve IgG4-related disease in some patients. This subset shows increased inflammation and reduced bladder capacity, suggesting a distinct pathological pathway for this bladder pain syndrome.

Keywords:
Bladder pain syndromeIgG4-related diseaseInterstitial cystitisPlasma cells

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Published on: December 15, 2011

Area of Science:

  • Urology
  • Immunology
  • Pathology

Background:

  • Interstitial cystitis (IC) is a chronic bladder condition with unknown causes.
  • Inflammation, particularly mast cell infiltration, is implicated in IC pathogenesis.
  • The role of plasma cells in IC requires further investigation.

Purpose of the Study:

  • To investigate the potential role of IgG4-related disease in a subset of interstitial cystitis patients.
  • To examine the presence and significance of IgG4-positive plasma cells in bladder tissue from IC patients.

Main Methods:

  • Histological examination and immunostaining for IgG, IgG4, and tryptase were performed on 44 IC patient samples.
  • Clinical and cystoscopic findings were correlated with immunohistochemical results.
  • Cases were categorized based on the presence and density of IgG4-positive plasma cells.

Main Results:

  • Four cases (approximately 9%) exhibited a significant increase in IgG4-positive plasma cells (>30 per high-power field) and an IgG4/IgG ratio > 0.5.
  • IC patients with elevated IgG4-positive plasma cells were older and presented with more severe inflammation and reduced bladder capacity compared to IgG4-negative cases.
  • Statistically significant differences were observed between the IgG4-positive and IgG4-negative IC patient groups.

Conclusions:

  • A subset of interstitial cystitis patients may represent a manifestation of IgG4-related disease.
  • Further research, including serum IgG4 level assessment, is warranted to confirm this association.
  • Identifying IgG4-related disease in IC could lead to targeted therapies for this specific patient group.