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Updated: May 10, 2026
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Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
Published on: March 13, 2012
[Chronic inflammatory sensory polyradiculopathy]
Paz Zuberbuhler1, Diego Miñarro, Daniela Binaghi
1Departamento de Neurología, Hospital Británico. pachizuber@gmail.com
Medicina
|June 5, 2013
Summary
Chronic inflammatory sensory polyradiculopathy (CIDP), a treatable condition, presents with sensory ataxia and normal nerve conduction. Early diagnosis via MRI and response to immunotherapy are key.
Area of Science:
- Neurology
- Neuroimmunology
Background:
- Chronic inflammatory sensory polyradiculopathy (CISP) is an underdiagnosed neurological disorder.
- Suspected in patients with sensory ataxia, normal nerve conduction studies, and specific MRI findings.
Observation:
- A 57-year-old man presented with severe sensory ataxia, reduced reflexes, and sensory loss below the knees.
- Nerve conduction studies were normal, but tibial sensory evoked potentials were absent.
- MRI revealed thickened, gadolinium-enhancing lumbosacral nerve roots.
Findings:
- Cerebrospinal fluid showed elevated protein without cells.
- The patient responded well to intravenous immunoglobulin (IVIg) therapy.
- Diagnosis of CISP was supported by clinical presentation, MRI, CSF findings, and immunotherapy response.
Implications:
- Highlights the importance of suspecting CISP in cases of unexplained sensory ataxia.
- Emphasizes the diagnostic utility of MRI and evoked potentials in CISP.
- Suggests immunotherapy, such as IVIg, as an effective treatment for CISP.
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