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Related Concept Videos

Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

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Related Experiment Video

Updated: May 10, 2026

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
08:23

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

[Chronic inflammatory sensory polyradiculopathy].

Paz Zuberbuhler1, Diego Miñarro, Daniela Binaghi

  • 1Departamento de Neurología, Hospital Británico. pachizuber@gmail.com

Medicina
|June 5, 2013
PubMed
Summary
This summary is machine-generated.

Chronic inflammatory sensory polyradiculopathy (CIDP), a treatable condition, presents with sensory ataxia and normal nerve conduction. Early diagnosis via MRI and response to immunotherapy are key.

Keywords:
chronic inflammatory polyradiculopathysensory ataxia

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Last Updated: May 10, 2026

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
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Published on: January 21, 2020

Area of Science:

  • Neurology
  • Neuroimmunology

Background:

  • Chronic inflammatory sensory polyradiculopathy (CISP) is an underdiagnosed neurological disorder.
  • Suspected in patients with sensory ataxia, normal nerve conduction studies, and specific MRI findings.

Observation:

  • A 57-year-old man presented with severe sensory ataxia, reduced reflexes, and sensory loss below the knees.
  • Nerve conduction studies were normal, but tibial sensory evoked potentials were absent.
  • MRI revealed thickened, gadolinium-enhancing lumbosacral nerve roots.

Findings:

  • Cerebrospinal fluid showed elevated protein without cells.
  • The patient responded well to intravenous immunoglobulin (IVIg) therapy.
  • Diagnosis of CISP was supported by clinical presentation, MRI, CSF findings, and immunotherapy response.

Implications:

  • Highlights the importance of suspecting CISP in cases of unexplained sensory ataxia.
  • Emphasizes the diagnostic utility of MRI and evoked potentials in CISP.
  • Suggests immunotherapy, such as IVIg, as an effective treatment for CISP.