Related Experiment Video
Updated: May 10, 2026
08:34
Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Adipocytokines and aging: adiponectin and leptin
N E Gulcelik1, M Halil, S Ariogul
1Department of Endocrinology and Metabolism, Hacettepe Medical School, Ankara, Turkey. neseersoz@hotmail.com
Minerva Endocrinologica
|June 5, 2013
Summary
Aging alters adipose tissue and adipocytokines like adiponectin and leptin, impacting metabolic health and disease risk. Dysregulated adiponectin in older adults may increase mortality, while leptin
Area of Science:
- Endocrinology
- Metabolism
- Gerontology
Background:
- Adipose tissue is a key metabolic organ producing adipocytokines crucial for energy balance, glucose, and lipid metabolism.
- Aging causes fat redistribution (less subcutaneous, more visceral) and alters adipocyte function, impacting adipocytokine secretion and function.
- Visceral adipose tissue is more implicated in metabolic diseases than subcutaneous adipose tissue.
Purpose of the Study:
- To review the roles of adiponectin and leptin in aging and age-related diseases.
- To discuss how aging affects the secretion, function, and levels of these key adipocytokines.
- To explore the implications of adipocytokine dysregulation in older populations.
Main Methods:
- Literature review of studies on adipocytokines, aging, and age-related diseases.
- Analysis of research on adiponectin and leptin in centenarians and individuals aged 65+.
- Synthesis of findings regarding aging-associated changes in adipocytokine signaling and receptor function.
Main Results:
- Centenarians exhibit higher adiponectin levels linked to longevity.
- In individuals 65+, elevated adiponectin is paradoxically associated with increased mortality, possibly due to reduced function or inflammation.
- Aging may lead to leptin resistance or decreased leptin receptor expression, with conflicting reports on leptin's role in age-related diseases.
Conclusions:
- Adiponectin and leptin levels and functions are significantly altered by aging.
- Dysregulation of adiponectin in older adults presents a complex relationship with mortality.
- Further research is needed to clarify the precise roles of adiponectin and leptin in age-related conditions like sarcopenia, Alzheimer's, and cardiovascular disease.
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