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09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Uhthoff's phenomena in MS--clinical features and pathophysiology.
Teresa C Frohman1, Scott L Davis, Shin Beh
1Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Centre, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA.
Nature Reviews. Neurology
|June 5, 2013
Summary
Uhthoff's phenomena are temporary neurological symptoms in multiple sclerosis (MS) triggered by heat or stress. Unlike MS relapses, these episodes stem from ion channel changes in demyelinated nerves.
Area of Science:
- Neurology
- Neuroscience
- Ophthalmology
Background:
- Uhthoff's phenomena, first described in the late 19th century, are transient neurological symptoms.
- These phenomena are characteristic of multiple sclerosis (MS) and other demyelinating diseases.
Observation:
- Symptoms are recurrent, stereotyped, paroxysmal, short-lived, and reversible.
- Triggers include fever, exercise, heat exposure, stress, and the perimenstrual period.
Findings:
- Uhthoff's phenomena result from ion channel modifications and thermoregulatory dysfunction.
- These factors transiently impair conduction in demyelinated axons.
- Distinguishing Uhthoff's phenomena from MS exacerbations is crucial for appropriate management.
Implications:
- Understanding the pathophysiology aids in recognizing and treating Uhthoff's phenomena.
- This knowledge is vital for managing patients with MS and related conditions.
- Accurate diagnosis prevents misinterpretation as disease progression or relapse.
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