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Related Experiment Videos

Histoplasmomas of uncommon size.

Bradley W Richmond1, John A Worrell2, Julie A Bastarache1

  • 1Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN.

Chest
|June 5, 2013
PubMed
Summary

Giant histoplasmomas, larger than 3 cm, are rare and can mimic malignancy. These "cannonball" histoplasmomas may present with atypical symptoms, challenging diagnosis.

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Radiology

Background:

  • Histoplasma capsulatum infection causes diverse clinical presentations, ranging from acute to chronic.
  • Chronic histoplasmosis complications often stem from prolonged host immune responses with minimal fungal presence.
  • Pulmonary nodules, or histoplasmomas, can persist for decades and pose diagnostic challenges, often resembling tumors or tuberculomas.

Observation:

  • Histoplasmomas are typically small (<1 cm), asymptomatic, and stable or slowly growing.
  • This study details three cases of unusually large, or giant, histoplasmomas (>3 cm) exhibiting an extreme phenotype.
  • Two patients presented with subacute symptomatic disease, an atypical presentation for histoplasmoma.

Findings:

  • Giant histoplasmomas (>3 cm) represent an extreme phenotype of pulmonary histoplasmosis.

Related Experiment Videos

  • Atypical presentations, including subacute symptoms, were observed in patients with giant histoplasmomas.
  • The term "cannonball" histoplasmoma is proposed for these large masses, distinct from "buckshot" calcifications.

    • Implications:

    • The findings expand the clinical spectrum of histoplasmoma presentation.
    • "Cannonball" histoplasmoma may aid in differentiating these rare, large nodules from other pulmonary pathologies.
    • Recognizing atypical presentations is crucial for accurate diagnosis and management of histoplasmoma.