Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural changes in cryopreserved tracheal grafts of sprague-dawley rats.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2009
Same author

Facile synthesis of size-tunable micro-octahedra via metal-organic coordination.

Chemical communications (Cambridge, England)·2009
Same author

N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway.

Molecular carcinogenesis·2009
Same author

Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs.

Breast cancer research and treatment·2009
Same author

N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha.

Journal of cellular biochemistry·2009
Same author

A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo.

Cancer immunology, immunotherapy : CII·2009

Related Experiment Video

Updated: May 10, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Comparative studies on ectopic bone formation in porous hydroxyapatite scaffolds with complementary pore structures.

Hao Wang1, Wei Zhi, Xiong Lu

  • 1Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.

Acta Biomaterialia
|June 5, 2013
PubMed
Summary

Hydroxyapatite scaffolds with specific pore structures promote vascularized bone formation. Spherulite HA-positive scaffolds demonstrated superior osteoinduction and vascularization compared to porogen HA-negative scaffolds.

Keywords:
Hydroxyapatite porous scaffoldMacro-pore structureOsteoinductionVascularization

More Related Videos

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Related Experiment Videos

Last Updated: May 10, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Research

Background:

  • Vascularized bone grafts are crucial for bone defect repair.
  • Hydroxyapatite (HA) scaffolds offer potential for bone regeneration.
  • Optimizing scaffold pore structure is key for successful bone formation and vascularization.

Purpose of the Study:

  • To investigate the impact of macro-pore structure on ectopic bone formation using hydroxyapatite scaffolds.
  • To compare the osteoinductive and vascularization capabilities of two distinct HA scaffold types.

Main Methods:

  • Fabrication of two types of hydroxyapatite (HA) scaffolds: spherulite HA-positive and porogen HA-negative, with complementary macro-pore structures.
  • Implantation of scaffolds into the dorsal muscle of dogs.
  • Histological and mechanical property analysis at 1, 3, and 6 months post-implantation.

Main Results:

  • Both scaffold types exhibited excellent biocompatibility and pore interconnectivity.
  • Spherulite HA-positive scaffolds showed significantly enhanced osteoinduction, with more osteoblasts and osteoclasts, and new bone formation compared to porogen HA-negative scaffolds.
  • Improved mechanical properties and material reconstruction were observed in spherulite HA-positive scaffolds.

Conclusions:

  • Macro-pore structure significantly influences osteoinduction and vascularization in intramuscular implantation.
  • Spherulite HA-positive scaffolds demonstrate superior performance for vascularized bone graft applications.
  • Tailoring scaffold macro-pore architecture is critical for enhancing bone regeneration outcomes.