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Related Experiment Video

Updated: May 10, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Visual field defects due to optic disk drusen in children.

Susana Noval1, Josep Visa, Inés Contreras

  • 1Pediatric Ophthalmology Department, La Paz University Hospital, Paseo de la Castellana 261, 28046, Madrid, Spain, sunoval@gmail.com.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|June 5, 2013
PubMed
Summary

Optic nerve head drusen (ONHD) can cause visual field defects in children. Optical coherence tomography (OCT) shows increased retinal nerve fiber layer (RNFL) thickness in early stages, decreasing as drusen become superficial.

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Area of Science:

  • Ophthalmology
  • Pediatric ophthalmology
  • Neuro-ophthalmology

Background:

  • Optic nerve head drusen (ONHD) are associated with axonal metabolism and degeneration.
  • Previous research on ONHD has primarily focused on adult populations.
  • The impact of ONHD on pediatric visual function and optic nerve structure remains less understood.

Purpose of the Study:

  • To investigate the effects of ONHD on visual function in children.
  • To analyze optic nerve head structure in pediatric patients with ONHD using optical coherence tomography (OCT).
  • To correlate structural changes with visual field defects in affected children.

Main Methods:

  • Inclusion criteria: Children under 18 with ONHD and reliable visual field defects.
  • Ophthalmic examination: Best-corrected visual acuity (BCVA), funduscopy, standard automated perimetry (SITA 24-2).
  • Imaging: OCT (Cirrus-HD Model 4000) for retinal nerve fiber layer (RNFL) thickness, compared to age-matched healthy controls.

Main Results:

  • Fifteen children (mean age 13 years) were included; ONHD were bilateral in 13.
  • Visual field defects were present in 26 of 28 affected eyes (7% showed no defect). Common defects included nasal (54%) and constricted visual fields (21%).
  • RNFL thickness: Increased in type 1 (buried) and type 2 (ringed) ONHD; decreased in type 3 (superficial) ONHD compared to controls.

Conclusions:

  • ONHD can lead to visual field defects in children, even in early stages.
  • OCT reveals initial RNFL thickening followed by thinning as ONHD progress and become superficial.
  • Preservation of the temporal quadrant may explain the maintenance of central visual acuity.