Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced vapor wall loss of intermediate volatility alcohols at elevated relative humidity.

Aerosol science and technology : the journal of the American Association for Aerosol Research·2026
Same author

Social Media Intensity and Chinese Female Undergraduates' Attitudes Toward Marriage: The Roles of Benevolent Sexism and the Need to Belong.

International journal of sexual health : official journal of the World Association for Sexual Health·2026
Same author

Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries.

medRxiv : the preprint server for health sciences·2026
Same author

Dual functionalization of steviol enables mitochondrial targeting and redox modulation in antitumor therapy.

European journal of medicinal chemistry·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Impact of COVID-19 on acute angle-closure attack: A retrospective study.

Medicine·2024
Same journal

Perimetric Outcomes of Melbourne Rapid Field Perimetry in Patients With Glaucoma: A Systematic Review and Meta-Analysis.

Journal of glaucoma·2026
Same journal

Rethinking Dry Eye and Ocular Surface Disease in Glaucoma: Pathophysiology, Diagnosis, and Management.

Journal of glaucoma·2026
Same journal

Outcome of Gonioscopy-Assisted Transluminal Trabeculotomy in Uveitic Glaucoma.

Journal of glaucoma·2026
Same journal

"Letter to the Editor: Myopic Shift Induced By Omidenepag Isopropyl 0.002% in Patients With Primary Open-Angle Glaucoma, Jan 2026.

Journal of glaucoma·2026
Same journal

Comparative Evaluation of Functional Aqueous Humor Outflow in Primary Open Angle Glaucoma versus Primary Angle Closure Glaucoma using Aqueous Angiography.

Journal of glaucoma·2026
Same journal

Patient and Neighborhood Factors Influencing Glaucoma Medication Adherence.

Journal of glaucoma·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

Intracranial pressure and glaucoma.

Jost B Jonas1, Diya Yang, Ningli Wang

  • 1Department of Ophthalmology, Medical Faculty Mannheim-Heidelberg, Mannheim, Germany.

Journal of Glaucoma
|June 5, 2013
PubMed
Summary
This summary is machine-generated.

Low cerebrospinal fluid pressure (CSFP) may contribute to normal-tension glaucoma development. This pressure, along with blood pressure, influences optic nerve damage beyond intraocular pressure (IOP).

More Related Videos

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Related Experiment Videos

Last Updated: May 10, 2026

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Glaucoma's optic nerve damage can occur with normal or high intraocular pressure (IOP).
  • Factors beyond IOP, such as cerebrospinal fluid pressure (CSFP), may influence glaucomatous optic neuropathy.
  • Optic nerve head appearance in normal-tension glaucoma differs from vascular optic neuropathies.

Purpose of the Study:

  • To investigate the role of cerebrospinal fluid pressure (CSFP) in the pathogenesis of normal-tension glaucoma.
  • To explore the relationship between CSFP, intraocular pressure (IOP), and optic nerve damage.

Main Methods:

  • Review of clinical and experimental studies linking CSFP, systemic arterial blood pressure, IOP, and body mass index.
  • Analysis of CSFP in cats with glaucomatous optic nerve damage.
  • Comparison of CSFP and trans-lamina cribrosa pressure difference in normal-tension glaucoma patients versus normal subjects.

Main Results:

  • Low CSFP is associated with glaucomatous optic nerve damage in cats.
  • Normal-tension glaucoma patients exhibit significantly lower CSFP compared to normal individuals.
  • Orbital CSFP acts as a retro-laminar counter-pressure against IOP, influencing the trans-lamina cribrosa pressure difference.

Conclusions:

  • Low orbital CSFP is implicated in the pathogenesis of normal-tension glaucoma.
  • Elevated trans-lamina cribrosa pressure difference and gradient, influenced by low CSFP, may cause glaucomatous optic nerve damage.
  • Low blood pressure may indirectly contribute to normal-tension glaucoma due to its association with CSFP.