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Updated: May 10, 2026
Alternative Methods for the Detection of Superoxide Anion Generation in Platelets
Published on: March 29, 2024
Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats
Premysl Mladenka1, Libuse Zatloukalova, Tomas Filipsky
1Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic. mladenkap@faf.cuni.cz
Background:
Predicting cardiovascular events remains challenging despite the range of known biomarkers.
Aim:
To establish relationships between various biochemical and functional parameters of the cardiovascular system.
Method:
The relationship between cardiovascular dys/function and various biomarkers was examined in 145 experimental rats half of which received isoprenaline 100 mg/kg s.c. to induce cardiac impairment.
Results:
Serum concentration of cardiac troponin T (cTnT), a known marker of cardiac derangement, correlated strongly with degree of myocardial injury (e.g. calcium overload, stroke volume) but correlations between cTnT and oxidative stress parameters were weak (for glutathione and vitamin C) or not found (for serum vitamin E and plasma thiobarbituric acid reactive substances levels). Relationships between cTnT and other parameters were exponential with the exception of myocardial calcium, where a power function was found.
Conclusions:
Commonly used biomarkers of oxidative stress cannot reliably predict cardiovascular dys/function in experimental rats.
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