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Related Experiment Video

Updated: May 10, 2026

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Published on: March 13, 2018

Ocular manipulation reduces both ipsilateral and contralateral electroretinograms.

Jasmine H Francis¹, David H Abramson, Brian P Marr

¹Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Documenta Ophthalmologica. Advances in Ophthalmology

|June 5, 2013

Summary

Ocular manipulation, including transpupillary thermotherapy and scleral depression, significantly reduces electroretinogram (ERG) photopic response in both treated and healthy fellow eyes. This finding helps explain variations in ERG recordings after ocular procedures.

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Published on: February 15, 2022

Area of Science:

Ophthalmology
Retinoblastoma Research
Electrophysiology

Background:

Retinoblastoma is a pediatric eye cancer requiring various treatment modalities.
Electroretinogram (ERG) is a key diagnostic tool for assessing retinal function in ocular diseases.
Understanding ERG changes post-manipulation is crucial for accurate interpretation.

Purpose of the Study:

To evaluate electroretinogram (ERG) changes after ocular manipulation in retinoblastoma patients.
To compare ERG responses in manipulated eyes versus untouched fellow eyes.
To investigate the impact of transpupillary thermotherapy (TTT), cryotherapy, and scleral depression on ERG.

Main Methods:

Prospective observational study of 73 ERG tests in 42 retinoblastoma patients.
ERG recordings were taken before and after ocular manipulation (TTT, cryotherapy, scleral depression).
Included manipulation of diseased eyes and fellow healthy eyes, as well as control periods.

Main Results:

Photopic response significantly decreased in both treated and fellow healthy eyes after local ablative treatment.
Scleral depression of the diseased eye reduced photopic response in both the diseased (21%) and fellow healthy (23%) eyes.
Scleral depression of the fellow healthy eye reduced photopic response in the healthy eye (4%) and diseased eye (28%).

Conclusions:

Physical ocular manipulation leads to decreased photopic ERG amplitude in both manipulated and untouched fellow eyes.
These ERG amplitude changes may explain variability in clinical recordings post-ocular manipulation.
Findings are relevant for interpreting ERGs following TTT, laser therapy, or scleral depression.