Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laser-boosted microscopy opens view of elusive proteins.

Science (New York, N.Y.)·2026
Same author

Patently imperfect<b>Pharma Monopoly</b> <i>Tahir Amin and Rohit Malpani</i> Polity, 2026. 256 pp.

Science (New York, N.Y.)·2026
Same author

At last, a pill that can prevent COVID after exposure to infected people.

Nature·2026
Same author

All life runs on 20 amino acids. These cells run key machinery on just 19.

Nature·2026
Same author

Into the deep.

Science (New York, N.Y.)·2026
Same author

Why teens with ADHD are so vulnerable to the perils of social media.

Nature·2026

Related Experiment Video

Updated: May 10, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Cancer's true breakthroughs.

Elie Dolgin

    Nature Medicine
    |June 5, 2013
    PubMed
    Summary

    A new regulatory pathway accelerates promising drugs to market, primarily benefiting cancer patients. This allows faster access to innovative treatments for those newly diagnosed with cancer in the US.

    Area of Science:

    • Pharmacology
    • Oncology
    • Regulatory Science

    Background:

    • A recent regulatory pathway enables expedited approval for drugs demonstrating significant early clinical promise.
    • This pathway has predominantly been utilized for novel cancer therapeutics.

    Discussion:

    • The implications of accelerated drug approval for cancer treatment accessibility are profound.
    • Understanding the characteristics that define 'breakthrough' medicines is crucial for leveraging this new pathway.

    Key Insights:

    • The 'breakthrough designation' facilitates faster market entry for drugs with exceptional early-stage clinical data.
    • Cancer agents represent the majority of drugs receiving this designation, highlighting a focus on oncological advancements.
    • This regulatory shift promises quicker access to cutting-edge therapies for the substantial daily influx of new cancer diagnoses in the US.

    More Related Videos

    Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
    10:27

    Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

    Published on: July 25, 2020

    Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
    07:50

    Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

    Published on: April 18, 2025

    Related Experiment Videos

    Last Updated: May 10, 2026

    Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
    07:29

    Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

    Published on: June 20, 2015

    Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
    10:27

    Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

    Published on: July 25, 2020

    Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
    07:50

    Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

    Published on: April 18, 2025

    Outlook:

    • Future research should explore the long-term impact of these expedited approvals on patient outcomes and healthcare systems.
    • Continued analysis of breakthrough designation criteria may refine the process for other therapeutic areas.