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Updated: May 10, 2026

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
Published on: July 6, 2022
Geospatial (s)tools: integration of advanced epidemiological sampling and novel diagnostics
Giuseppe Cringoli1, Laura Rinaldi, Marco Albonico
1Unit of Parasitology and Parasitic Diseases, Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via della Veterinaria 1, Naples, Italy. cringoli@unina.it
Intensified research is crucial for parasitic disease elimination, despite political commitment. Innovative tools and integrated strategies are needed to overcome funding challenges and ensure long-term control.
Area of Science:
- Public Health
- Infectious Diseases
- Parasitology
Background:
- Global efforts are underway for large-scale control and elimination of parasitic diseases.
- Political commitment is strong, but declining funding and lack of novel tools pose significant challenges.
Purpose of the Study:
- To highlight the urgent need for intensified research and development in parasitic disease control.
- To emphasize the integration of advanced epidemiological, diagnostic, and geospatial methodologies.
Main Methods:
- Discusses advances in epidemiological sampling, including cluster-randomised sampling.
- Highlights innovative diagnostic tools like Mini-FLOTAC for detecting parasitic elements and pooling samples.
- Incorporates high-resolution geospatial methodologies for disease mapping and analysis.
Main Results:
- Integration of sound epidemiological designs with innovative diagnostics and geospatial tools is essential.
- Standardization of quality procedures and validation of new tools are critical for progress.
- Addressing challenges in funding and intervention coverage is necessary for sustained control.
Conclusions:
- Sustained control and eventual elimination of parasitic diseases require continuous innovation and validation of tools and strategies.
- Integrating advanced methodologies and ensuring quality standards are key to overcoming current obstacles.
- Addressing funding and coverage gaps is vital for achieving public health goals in human and veterinary medicine.
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