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Related Experiment Video

Updated: May 10, 2026

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Published on: January 26, 2024

Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task.

Nicolas W Schuck¹, Christian F Doeller, Brit-Maren M Schjeide

¹Max Planck Institute for Human Development, Center for Lifespan Psychology, 14195 Berlin, Germany; Department of Psychology, Humboldt-Universität zu Berlin, 10099 Berlin, Germany.

|June 5, 2013

Summary

Older adults rely more on landmark spatial memory, while younger adults use boundary cues. A KIBRA gene variant (rs17070145) impacts spatial learning in older individuals.

Keywords:

KIBRA aging hippocampus spatial navigation striatum

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Area of Science:

Neuroscience
Cognitive Psychology
Genetics

Background:

Spatial navigation involves distinct memory systems, with younger adults utilizing hippocampal (boundary) and striatal (landmark) pathways.
Aging may alter the reliance on these spatial memory mechanisms.

Purpose of the Study:

To investigate age-related differences in spatial memory reliance on landmark versus boundary information.
To examine the influence of the KIBRA gene polymorphism (rs17070145) on spatial learning in aging.

Main Methods:

A virtual reality navigation paradigm was employed to assess spatial learning.
Participants' spatial memory strategies and performance were analyzed in relation to age and KIBRA genotype.

Main Results:

Older adults showed a greater reliance on landmark information for spatial learning compared to younger adults.
Younger adults preferentially utilized boundary information.
Among older adults, T-allele carriers of the KIBRA rs17070145 polymorphism exhibited enhanced spatial learning compared to C homozygotes.

Conclusions:

Human spatial memory strategies shift with age, with a greater emphasis on landmark processing in older adults.
The KIBRA rs17070145 polymorphism influences spatial learning in older individuals, suggesting a genetic component to age-related cognitive changes.