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Updated: May 10, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Achiral-to-chiral transition in benzil solidification: analogies with racemic conglomerates systems showing
Zoubir El-Hachemi1, Oriol Arteaga, Adolf Canillas
1Departament de Química Orgànica, Universitat de Barcelona (IEEC-UB), Barcelona, Catalonia, Spain.
Abstract:
Experimental results show that benzil (1,2-diphenyl-1,2-ethanedione), an achiral compound that crystallizes as a racemic conglomerate, yields by solidification polycrystalline scalemic mixtures of high enantiomeric excesses. These results are related to those previously reported in this type of compounds on deracemizations of racemic mixtures of crystal enantiomorphs obtained by wet grinding. However, the present results strongly suggest that these experiments cannot be explained without taking into account chiral recognition interactions at the level of precritical clusters. The conditions that would define a general thermodynamic scenario for such deracemizations are discussed.
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