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Socio-emotional Problems in Children with CDG
K F E van de Loo1, L van Dongen, M Mohamed
1Department of Medical Psychology, Radboud University Medical Centre, Nijmegen, The Netherlands.
JIMD Reports
|June 5, 2013
Summary
Children with Congenital Disorders of Glycosylation (CDG) experience a high prevalence of socio-emotional problems, including withdrawn/depressed behavior and social difficulties. Early psychological screening is recommended for these patients.
Area of Science:
- Pediatric Neurology
- Metabolic Disorders
- Neurodevelopmental Disorders
Background:
- Congenital Disorders of Glycosylation (CDG) are inherited metabolic diseases often affecting the nervous system.
- Parents report behavioral issues like anxiety and depression in CDG patients.
- This suggests a potential link between CDG and socio-emotional difficulties.
Purpose of the Study:
- To investigate the prevalence of socio-emotional problems in children with CDG.
- To assess if CDG patients have an increased risk for psychological challenges.
Main Methods:
- Evaluated 18 children diagnosed with CDG.
- Utilized the Child Behavior Checklist (CBCL) for socio-emotional screening.
- Employed the Nijmegen Paediatric CDG Rating Scale (NPCRS) for disease severity assessment.
- Compared results to normative data and control groups (mitochondrial and other chronic metabolic disorders).
Main Results:
- Children with CDG exhibited a high rate of socio-emotional problems.
- Significantly elevated scores were observed for overall problems, withdrawn/depressed behavior, social issues, and somatic complaints.
- Over two-thirds of CDG patients showed abnormal CBCL scores.
- Social problem scores were notably higher in CDG patients compared to control groups.
Conclusions:
- CDG patients face an increased risk of developing socio-emotional problems.
- Routine psychological screening is advised for early identification and management of these issues in CDG.
- This highlights the importance of addressing the psychological well-being of children with CDG.
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