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Socio-emotional Problems in Children with CDG

K F E van de Loo1, L van Dongen, M Mohamed

  • 1Department of Medical Psychology, Radboud University Medical Centre, Nijmegen, The Netherlands.

JIMD Reports
|June 5, 2013
PubMed

Insights

Children with Congenital Disorders of Glycosylation (CDG) experience a high prevalence of socio-emotional problems, including withdrawn/depressed behavior and social difficulties. Early psychological screening is recommended for these patients.

Area of Science:

  • Pediatric Neurology
  • Metabolic Disorders
  • Neurodevelopmental Disorders

Background:

  • Congenital Disorders of Glycosylation (CDG) are inherited metabolic diseases often affecting the nervous system.
  • Parents report behavioral issues like anxiety and depression in CDG patients.
  • This suggests a potential link between CDG and socio-emotional difficulties.

Purpose of the Study:

  • To investigate the prevalence of socio-emotional problems in children with CDG.
  • To assess if CDG patients have an increased risk for psychological challenges.

Main Methods:

  • Evaluated 18 children diagnosed with CDG.
  • Utilized the Child Behavior Checklist (CBCL) for socio-emotional screening.
  • Employed the Nijmegen Paediatric CDG Rating Scale (NPCRS) for disease severity assessment.
  • Compared results to normative data and control groups (mitochondrial and other chronic metabolic disorders).

Main Results:

  • Children with CDG exhibited a high rate of socio-emotional problems.
  • Significantly elevated scores were observed for overall problems, withdrawn/depressed behavior, social issues, and somatic complaints.
  • Over two-thirds of CDG patients showed abnormal CBCL scores.
  • Social problem scores were notably higher in CDG patients compared to control groups.

Conclusions:

  • CDG patients face an increased risk of developing socio-emotional problems.
  • Routine psychological screening is advised for early identification and management of these issues in CDG.
  • This highlights the importance of addressing the psychological well-being of children with CDG.
Abstract

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