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Related Concept Videos

Socioemotional Development during Infancy01:30

Socioemotional Development during Infancy

Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
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Related Experiment Video

Updated: May 10, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
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Socio-emotional Problems in Children with CDG.

K F E van de Loo1, L van Dongen, M Mohamed

  • 1Department of Medical Psychology, Radboud University Medical Centre, Nijmegen, The Netherlands.

JIMD Reports
|June 5, 2013
PubMed
Summary

Children with Congenital Disorders of Glycosylation (CDG) experience a high prevalence of socio-emotional problems, including withdrawn/depressed behavior and social difficulties. Early psychological screening is recommended for these patients.

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Area of Science:

  • Pediatric Neurology
  • Metabolic Disorders
  • Neurodevelopmental Disorders

Background:

  • Congenital Disorders of Glycosylation (CDG) are inherited metabolic diseases often affecting the nervous system.
  • Parents report behavioral issues like anxiety and depression in CDG patients.
  • This suggests a potential link between CDG and socio-emotional difficulties.

Purpose of the Study:

  • To investigate the prevalence of socio-emotional problems in children with CDG.
  • To assess if CDG patients have an increased risk for psychological challenges.

Main Methods:

  • Evaluated 18 children diagnosed with CDG.
  • Utilized the Child Behavior Checklist (CBCL) for socio-emotional screening.
  • Employed the Nijmegen Paediatric CDG Rating Scale (NPCRS) for disease severity assessment.
  • Compared results to normative data and control groups (mitochondrial and other chronic metabolic disorders).

Main Results:

  • Children with CDG exhibited a high rate of socio-emotional problems.
  • Significantly elevated scores were observed for overall problems, withdrawn/depressed behavior, social issues, and somatic complaints.
  • Over two-thirds of CDG patients showed abnormal CBCL scores.
  • Social problem scores were notably higher in CDG patients compared to control groups.

Conclusions:

  • CDG patients face an increased risk of developing socio-emotional problems.
  • Routine psychological screening is advised for early identification and management of these issues in CDG.
  • This highlights the importance of addressing the psychological well-being of children with CDG.