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Updated: May 10, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
The immunological identity of tumor: Self implications
Jason Miska1, Priyadharshini Devarajan, Zhibin Chen
1Department of Microbiology & Immunology; University of Miami Miller School of Medicine; Miami, FL USA.
Abstract:
By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.
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