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Effect of thyroxine on fibrinolytic system in rat

P Bubber1, A Chauhan, A Sharma

  • 1Discipline of Biochemistry, School of Sciences, Indira Gandhi National Open University, New Delhi--110 068. parveshbubber@hotmail.com

Indian Journal of Physiology and Pharmacology
|June 6, 2013
PubMed

Insights

Thyroxine treatment significantly increased heart plasminogen activators (PA) and reduced blood cholesterol levels in rats. This suggests potential benefits for cardiovascular risk by improving fibrinolysis and lipid profiles.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Biochemistry

Background:

  • Thyroid hormones influence cardiovascular health, impacting atherosclerosis and hemodynamic parameters.
  • Thyroid dysfunction is linked to dyslipidemia and alterations in the fibrinolytic system.
  • The precise role of thyroxine in regulating fibrinolytic components requires further elucidation.

Purpose of the Study:

  • To investigate the effects of thyroxine on cardiac plasminogen activators (PA).
  • To assess changes in plasma plasminogen activator (PA) and plasminogen activator inhibitor (PAI) levels.
  • To evaluate the impact of thyroxine on plasma glucose and serum lipid profiles in rats.

Main Methods:

  • Rats received intraperitoneal injections of eltroxine (50 ug/100 gm body weight) for one week.
  • Cardiac PA activity was measured.
  • Plasma levels of PA, PAI, glucose, and serum lipid profiles were analyzed.

Main Results:

  • Thyroxine treatment significantly elevated PA activity in rat hearts compared to controls.
  • No significant changes were observed in plasma PA, PAI, or glucose levels between groups.
  • Serum total cholesterol and LDL-cholesterol decreased, lowering LDL/HDL and Total cholesterol/HDL ratios.

Conclusions:

  • Thyroxine administration enhances cardiac PA activity.
  • Thyroxine treatment effectively reduces serum cholesterol levels and associated ratios.
  • These findings suggest thyroxine may offer protective cardiovascular benefits by modulating fibrinolysis and lipid metabolism.

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