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Updated: May 10, 2026

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Cell based therapy in Parkinsonism.

Johannes Pjm de Munter¹, Chongsik Lee, Erik Ch Wolters

¹Department of Neurosciences University Maastricht, Maastricht, The Netherlands. h.demunter@hetnet.nl.

Translational Neurodegeneration

|June 6, 2013

Summary

Adult stem cells (ASC) show promise for treating Parkinson's disease (PD) by potentially rescuing neurons and improving motor function. Clinical trials suggest neurorescue effects, particularly in early PD stages.

Area of Science:

Neuroscience
Regenerative Medicine
Stem Cell Biology

Background:

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions globally.
Current PD therapies are symptomatic, highlighting the need for neuroprotective strategies.
Adult stem cells (ASC) possess properties like transdifferentiation and immunomodulation, suggesting therapeutic potential.

Purpose of the Study:

To evaluate the efficacy of adult stem cells (ASC) as a neuroprotective strategy for Parkinson's disease (PD).
To investigate the potential of ASCs to promote neurorescue and improve motor function in PD models and patients.

Main Methods:

Preclinical studies utilized 6-hydroxydopamine (6-OHDA) and MPTP-lesioned animal models.
Histological and histochemical analyses assessed changes in Tyrosine Hydroxylase-positive (TH+) cells and dopamine levels.

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Limited clinical investigations involved subventricular or intravasal ASC applications in PD, MSA, and PSP patients.

Main Results:

ASC treatment in animal models led to persistent motor behavior improvements.
Intracerebral ASC application increased TH+ cells and striatal dopamine levels, indicating cell rescue.
Early-phase PD patients showed encouraging neurorescue with subventricular ASCs, while MSA/PSP patients had marginal benefits.

Conclusions:

ASCs demonstrate potential for neuroprotection and motor function improvement in Parkinson's disease.
Evidence suggests ASCs can promote neurorescue, particularly in the early stages of PD.
Further research is needed to optimize ASC therapy for various neurodegenerative conditions like MSA and PSP.