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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

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Related Experiment Video

Updated: May 10, 2026

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
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Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee.

Mireia Coscolla1, Astrid Lewin, Sonja Metzger

  • 1Swiss Tropical and Public Health Institute, Basel, Switzerland.

Emerging Infectious Diseases
|June 6, 2013
PubMed
Summary

A new Mycobacterium tuberculosis complex (MTBC) strain was discovered in a wild chimpanzee. This finding expands our understanding of MTBC diversity in African wildlife.

Keywords:
AfricaM. tuberculosisMTBCMycobacterium tuberculosisTBbacteriainfectionlineagemammalsnonhuman primatetuberculosistuberculosis and other mycobacteriawild chimpanzeezoonoses

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Area of Science:

  • Microbiology
  • Genomics
  • Evolutionary Biology

Background:

  • Tuberculosis (TB) is caused by Mycobacterium tuberculosis complex (MTBC) bacteria.
  • MTBC encompasses human-adapted lineages and variants found in domestic and wild animals.

Purpose of the Study:

  • To characterize a novel MTBC strain isolated from a wild chimpanzee.
  • To investigate the genetic diversity and evolutionary history of MTBC.

Main Methods:

  • Comparative genomic analysis
  • Phylogenomic analysis
  • Isolation of MTBC strain from wildlife

Main Results:

  • Identified a new MTBC lineage in a wild chimpanzee from Côte d'Ivoire.
  • The new lineage is phylogenetically closer to human-associated lineage 6 (M. africanum West Africa 2).
  • This discovery challenges the limited view of MTBC genetic diversity.

Conclusions:

  • The genetic diversity of MTBC is broader than previously understood.
  • Wild mammals in Africa may harbor undiscovered MTBC variants.
  • Further exploration of wildlife MTBC diversity is essential for understanding TB evolution and biology.