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Published on: October 2, 2020
Renal and mesenteric tissue oxygenation in preterm infants treated with oral ibuprofen
Nilufer Guzoglu1, Fatma Nur Sari, Ramazan Ozdemir
1Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey .
Insights
Oral ibuprofen preserved renal and mesenteric tissue oxygenation in preterm infants with significant patent ductus arteriosus (PDA). This study found no negative impact on regional hemodynamics, ensuring vital organ perfusion.
Area of Science:
- Neonatal physiology
- Pediatric cardiology
- Pharmacology
Background:
- Hemodynamically significant patent ductus arteriosus (PDA) is a prevalent complication in preterm infants, leading to substantial morbidities.
- While PDA affects tissue perfusion, data on oral ibuprofen's impact on regional tissue hemodynamics remains limited.
Purpose of the Study:
- To evaluate the effect of oral ibuprofen on renal and mesenteric tissue oxygenation and oxygen extraction in preterm infants with hemodynamically significant PDA.
- Utilized near-infrared spectroscopy (NIRS) to assess regional tissue hemodynamics.
Main Methods:
- Fifteen preterm infants (gestational age <32 weeks) with hemodynamically significant PDA treated with oral ibuprofen were enrolled.
- Renal and mesenteric oxygenation and oxygen extraction were monitored using NIRS.
- Control group comprised infants without PDA, matched for gestational and postnatal age.
Main Results:
- Infants with PDA exhibited significantly lower mean arterial blood pressure than controls (p < 0.001).
- No significant differences in renal and mesenteric oxygen saturation or fractional oxygen extraction were observed between PDA and control infants (p > 0.05).
- Oral ibuprofen treatment did not adversely affect renal and mesenteric oxygenation or extraction in infants with PDA (p > 0.05).
Conclusions:
- Renal and mesenteric tissue oxygenation and oxygen extraction are preserved in preterm infants with hemodynamically significant PDA treated with oral ibuprofen.
- Oral ibuprofen appears to be a safe therapeutic option regarding regional tissue perfusion in this vulnerable population.
Background:
Hemodynamically significant patent ductus arteriosus (PDA) is a common problem in preterm infants which often causes significant morbidities. Although PDA induces alterations in various tissue perfusion, there is scarce information about the effect of oral ibuprofen on hemodynamics of regional tissues.
Objective:
To investigate, using near-infrared spectroscopy, the effect of oral ibuprofen on renal and mesenteric tissue oxygenation and oxygen extraction in preterm infants with a diagnosis of hemodynamically significant PDA.
Patients And Methods:
Fifteen infants (gestational age <32 weeks) with the diagnosis of hemodynamically significant PDA treated with oral ibuprofen were monitored for near-infrared spectroscopy - determined renal and mesenteric oxygenation. The infants with PDA were matched for gestational age, postnatal age with infants without PDA, who served as control subjects.
Results:
In infants with PDA, mean arterial blood pressure was significantly lower compared with the control infants [39.3 (range:36-54) versus 51 (range:43-66) mmHg, respectively; p < 0.001)]. There were no significant differences in regional oxygen saturation and fractional oxygen extraction of renal and mesenteric tissues in PDA and control infants (p > 0.05). And ibuprofen treatment did not negatively influence renal and mesenteric oxygenation and extraction in infants with PDA (p > 0.05).
Conclusion:
Renal and mesenteric tissue oxygenation and oxygen extraction were preserved in preterm infants with a diagnosis of hemodynamically significant PDA treated with oral ibuprofen.
