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Comorbidity between hypomania and substance use disorders.

Elizabeth K Do¹, Briana Mezuk

¹Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P.O. Box 980126, Richmond, VA, USA. doek@vcu.edu

Journal of Affective Disorders

|June 6, 2013

Summary

Hypomania is linked to a higher risk of alcohol and drug abuse/dependence in adults. These associations were consistent across racial and ethnic groups, highlighting the importance of recognizing sub-syndromal conditions.

Keywords:

Hypomania Psychiatric comorbidity Substance abuse/dependence Substance use

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Area of Science:

Psychiatry
Epidemiology
Public Health

Background:

Bipolar disorder frequently co-occurs with substance use disorders.
Limited research exists on the general population's hypomania and substance misuse link.

Purpose of the Study:

To investigate the association between hypomania and substance misuse/dependence in the US adult population.
To examine if this association varies by race/ethnicity.

Main Methods:

Utilized data from the National Institute of Mental Health Collaborative Psychiatric Epidemiology Surveys (CPES) (N=10,404).
Employed multivariable regression to analyze DSM-IV hypomania and various substance use disorders (nicotine, alcohol, cannabis, cocaine, prescription drugs).
Adjusted for demographic factors and conducted stratified analyses for race/ethnicity.

Main Results:

The 12-month prevalence of hypomania was 0.5%, with higher rates among African Americans.
Individuals with hypomania were significantly more likely to have alcohol abuse/dependence (OR 3.6) and drug abuse/dependence (OR 2.9).
No significant variation in the hypomania-substance use association was found across racial/ethnic groups.

Conclusions:

Hypomania is associated with an increased likelihood of substance use and abuse/dependence across multiple substances.
These findings underscore the link between sub-syndromal hypomanic symptoms and community substance use.
The study's cross-sectional design limits causal inferences.