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Related Experiment Video

Updated: May 10, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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Connectomic approaches before the connectome.

Marco Catani1, Michel Thiebaut de Schotten, David Slater

  • 1Natbrainlab, King's College London, Institute of Psychiatry, Department of Forensic and Neurodevelopmental Sciences, London SE5 8AF, UK. m.catani@iop.kcl.ac.uk

Neuroimage
|June 6, 2013
PubMed
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This summary is machine-generated.

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The connectome, a map of neural connections, has evolved over centuries. Modern imaging methods offer quantitative insights, but a comprehensive human brain connectome remains a future goal.

Area of Science:

  • Neuroscience
  • Neuroanatomy
  • Systems Neuroscience

Background:

  • The concept of a neural map has been a long-standing pursuit in neuroscience.
  • Historical proto-connectome maps reflect the prevailing theories and methods of their time.
  • Contemporary connectome definitions build upon foundational neuronal theories from over a century ago.

Purpose of the Study:

  • To trace the historical development of anatomical and physiological concepts underpinning modern connectome definitions.
  • To evaluate the advancements and limitations of current connectomic approaches.
  • To contextualize the current enthusiasm for connectome mapping within its historical trajectory.

Main Methods:

  • Historical analysis of neuroscience concepts and mapping techniques.
Keywords:
ConnectionConnectomeDiffusionHodologyNetworksTractography

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  • Review of contemporary imaging and quantitative methods in connectomics.
  • Comparative assessment of historical and modern approaches to brain mapping.

    • Main Results:

    • Modern connectomics leverages advanced imaging techniques and quantitative methods for integrated analysis of structure, function, and behavior.
    • Despite progress, many current connectome maps are considered imperfect representations of true brain anatomy.
    • The development of a comprehensive human brain connectome is an ongoing and long-term endeavor.

    Conclusions:

    • Contemporary connectomic approaches represent a significant evolution from historical methods, benefiting from technological advancements.
    • Quantitative integration of structure, function, and behavior offers unique advantages in current connectome research.
    • A complete and accurate human brain connectome is still a distant objective, underscoring the complexity of the brain.