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Cronkhite-Canada syndrome with hypothyroidism.

A Pal1, S Sen, S Ghosh

  • 1Kothari Centre of Gastroenterology, Calcutta.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|July 1, 1990
PubMed
Summary

This case report details a patient with Cronkhite-Canada syndrome, a rare disorder causing gastrointestinal issues and skin changes. The study highlights the uncommon co-occurrence of this syndrome with hypothyroidism.

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Dermatology

Background:

  • Cronkhite-Canada syndrome (CCS) is a rare non-hereditary disorder characterized by gastrointestinal polyposis, abdominal pain, diarrhea, and protein-losing enteropathy.
  • Clinical manifestations often include alopecia, nail changes, and skin hyperpigmentation.

Observation:

  • An elderly male patient presented with non-familial gastrointestinal polyposis, malabsorption, and progressive hypoproteinemia.
  • The patient also exhibited alopecia, cutaneous hyperpigmentation, and nail dystrophy with onychomadesis, consistent with CCS.

Findings:

  • The patient was diagnosed with Cronkhite-Canada syndrome.
  • Concurrent hypothyroidism was identified in this patient.
  • The rare co-occurrence of CCS and hypothyroidism is discussed.

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Implications:

  • This case underscores the importance of considering endocrine disorders, specifically hypothyroidism, in patients diagnosed with Cronkhite-Canada syndrome.
  • Further research may elucidate sharedPathogenic mechanisms or the impact of hypothyroidism on CCS presentation.
  • Recognition of this association can aid in comprehensive patient management and improve clinical outcomes.