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Updated: May 10, 2026

Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase

Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase

Published on: June 16, 2008

HIV/AIDS eradication.

Matthew D Marsden¹, Jerome A Zack

¹Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, CA 90095, USA.

Bioorganic & Medicinal Chemistry Letters

|June 6, 2013

Summary

This summary is machine-generated.

Antiretroviral therapy suppresses HIV but doesn't cure it, as the virus persists in reservoirs. Innovative strategies like gene therapy and activation/elimination methods aim to eradicate HIV entirely.

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Last Updated: May 10, 2026

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Area of Science:

Immunology
Virology
Pharmacology

Background:

Antiretroviral therapy (ART) effectively inhibits human immunodeficiency virus (HIV) replication and prevents Acquired immunodeficiency syndrome (AIDS) progression.
ART is not curative, as HIV can persist in latent reservoirs, primarily in CD4+ T cells, during treatment.

Purpose of the Study:

To provide an overview of antiretroviral drugs' mechanisms and HIV persistence during therapy.
To outline innovative strategies for HIV eradication currently under development.

Main Methods:

Review of current understanding of HIV replication inhibition by ART.
Overview of mechanisms of viral persistence in latent reservoirs.
Description of emerging HIV eradication strategies, including gene therapy and shock-and-kill approaches.

Main Results:

ART suppresses viral load but does not eliminate latent HIV reservoirs.
Latent HIV reservoirs in CD4+ T cells pose a significant barrier to cure.
Novel strategies show promise for achieving complete HIV eradication.

Conclusions:

HIV eradication requires targeting latent viral reservoirs.
Gene therapy and activation/elimination approaches represent promising avenues for a functional HIV cure.
Further research into novel therapeutic agents is crucial for developing curative strategies.