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Cancer chemoprevention: a rapidly evolving field

W P Steward1, K Brown

  • 1Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK. wps1@leicester.ac.uk

British Journal of Cancer
|June 6, 2013
PubMed

Insights

Cancer chemoprevention uses agents to delay or reduce cancer. The field now emphasizes preclinical studies and biomarkers to predict treatment effectiveness.

Area of Science:

  • Oncology
  • Preventive Medicine

Background:

  • Cancer chemoprevention is the use of agents to reduce or delay malignancy.
  • Previous trials show promise in breast, prostate, and colon cancers.

Purpose of the Study:

  • To review the current state of cancer chemoprevention.
  • To highlight emerging developments in the field.

Main Methods:

  • Review of current literature on cancer chemoprevention.
  • Analysis of the evolving paradigm in agent development.
  • Focus on preclinical mechanistic evaluation and biomarker identification.

Main Results:

  • The field has shifted towards extensive preclinical evaluation.
  • Biomarkers are increasingly used to predict efficacy.
  • New strategies are emerging for cancer prevention.

Conclusions:

  • Cancer chemoprevention is a developing field with evolving methodologies.
  • Preclinical research and biomarker development are crucial for future success.
  • This review provides an overview of current advancements and future directions.

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