Diphosphonate immobilization on hydroxyapatite-coated titanium--method description
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Published on: February 23, 2017
Magáli Beck Guimarães1, Rodrigo Salbego Bueno, Micéli Beck Guimarães Blaya
1School of Dentistry, Centro Universitário Franciscano, Santa Maria, Rio Grande do Sul, Brazil. magaliguimaraes@gmail.com
Purpose:
The aim of this study was to promote the immobilization of a bone activity biomodulator (diphosphonate) on titanium, commonly used in implant dentistry, to provide a local method of delivering this drug during the osseointegration process.
Methods:
The implant material used in this study was commercially wrought titanium (Ticp), 99.9 mass%, grade II. From this material, discs of 15 mm diameter and 1 mm thick were fabricated. These discs underwent 3 sequential surface modification processes: (a) acid-etching, (b) hydroxyapatite coating, and (c) immersion in disodium pamidronate solution. Scanning electron microscopy, X-ray fluorescence, and X-ray diffraction analyses were carried out to characterize the surface created.
Results:
The results of these analyses demonstrate that the acid-etching process, followed by the sintering of hydroxyapatite particles and immersion in a solution of disodium pamidronate were effective for diphosphonate immobilization on the titanium surface.
Conclusions:
The methodology used in this study allows us to conclude that immersion of hydroxyapatite-coated titanium in a solution of diphosphonate was efficient to promote the immobilization of this drug on the titanium surface.
