Related Experiment Video
Updated: May 10, 2026

08:22
A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor
Published on: October 9, 2017
Postcastration analgesia in ponies using buprenorphine hydrochloride.
E J Love1, P M Taylor, H R Whay
1School of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, UK.
The Veterinary Record
|June 6, 2013
Summary
Buprenorphine effectively provided significant postoperative pain relief in ponies undergoing castration. This study demonstrates buprenorphine
Area of Science:
- Veterinary Anesthesiology
- Equine Pain Management
- Pharmacology
Background:
- Buprenorphine recently gained UK marketing authorization for horses.
- It offers long-lasting analgesic effects with potential for postoperative pain relief.
Purpose of the Study:
- To evaluate the efficacy of buprenorphine for postoperative analgesia in ponies.
- To assess pain in ponies undergoing castration after premedication with buprenorphine.
Main Methods:
- Observer-blinded, randomized study involving ponies undergoing castration.
- Ponies received either buprenorphine (0.01 mg/kg BW) or glucose intravenously before anesthesia.
- Pain was assessed using Dynamic Interactive Visual Analogue Scores (DIVAS) and Simple Descriptive Scale (SDS).
Main Results:
- Buprenorphine significantly reduced pain scores (DIVAS and SDS) compared to the control group.
- Fewer ponies in the buprenorphine group required rescue analgesia (3 vs. 5).
- No serious adverse effects were observed with buprenorphine administration.
Conclusions:
- Intravenous buprenorphine at 0.01 mg/kg BW before anesthesia provides effective postoperative analgesia in ponies after castration.
- Buprenorphine is a safe and valuable option for managing surgical pain in equine patients.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Analgesia and Pain Management
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

