NGS++: a library for rapid prototyping of epigenomics software tools

Area of Science:

• Bioinformatics
• Computational Genomics
• Software Development

Background:

• High-throughput sequencing data analysis is crucial for modern genomics.
• Existing frameworks facilitate access to tools but lack low-level programming libraries for faster development.
• There is a need for efficient, extensible libraries for genomic data manipulation.

Purpose of the Study:

• To introduce NGS++, a C++11 programming library designed for next-generation sequencing (NGS) datasets and genomic information files.
• To provide a versatile and extensible interface for reading, writing, and manipulating various genomic file formats.
• To facilitate rapid prototyping and development of genomics analysis tools, especially for epigenomics.

Main Methods:

• Developed NGS++ using C++11 standards.
• Implemented specialized data structures for genomic region and feature analysis.
• Focused on creating a common interface for data parsers and standardized internal data structures.

Main Results:

• NGS++ enables easy integration of new formats and rapid prototyping of functionalities.
• The library offers a powerful, versatile, and extensible interface for genomic file manipulation.
• Standardized internal data structures and a common parser interface provide an effective framework for epigenomics tool development.

Conclusions:

• NGS++ serves as an effective framework for developing epigenomics tools.
• The library simplifies the manipulation of NGS datasets and genomic information.
• It enhances the speed and ease of developing computational tools for genomics research.