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Vitamin D status and cardiometabolic assessment in infancy

Simone Kew1, Jill K Hamilton, Chang Ye

  • 1Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada.

Pediatric Research
|June 6, 2013
PubMed

Insights

Vitamin D insufficiency or deficiency in 1-year-old infants is not linked to adverse cardiometabolic risk factors. This study found no significant differences in key health markers regardless of vitamin D status.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Cardiovascular Health

Background:

  • Infants face high risk of vitamin D insufficiency due to limited sun exposure and low levels in breast milk.
  • Vitamin D insufficiency is linked to cardiometabolic risks in children, but this has not been studied in infants.
  • Infants have unique risks that warrant investigation into vitamin D status and cardiometabolic health.

Purpose of the Study:

  • To determine if vitamin D status is associated with cardiometabolic measures in 1-year-old infants.
  • Investigate the relationship between 25-hydroxy vitamin D levels and various cardiometabolic risk factors.
  • Assess traditional and emerging cardiometabolic markers in relation to infant vitamin D levels.

Main Methods:

  • Evaluated 99 full-term infants at 1 year of age.
  • Measured 25-hydroxy vitamin D (25-OH-D) and cardiometabolic risk factors (glucose, insulin, lipids, CRP, adiponectin, leptin).
  • Classified infants into vitamin D sufficient (n=59), insufficient (n=29), or deficient (n=11) groups based on 25-OH-D levels.

Main Results:

  • No significant differences in any cardiometabolic risk factors were observed among the three vitamin D groups.
  • Analyses were performed both unadjusted and adjusted for relevant covariates.
  • Vitamin D-deficient infants showed higher rates of exclusive breastfeeding and nonwhite ethnicity.

Conclusions:

  • Vitamin D insufficiency or deficiency is not associated with an adverse cardiometabolic risk factor profile in 1-year-old infants.
  • Current findings suggest that vitamin D status alone may not impact infant cardiometabolic health at this age.
  • Further research may explore other contributing factors to infant cardiometabolic health.
Abstract

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