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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: May 10, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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Immunotherapy of sarcomas.

John M Goldberg¹

¹Department of Pediatrics, University of Miami Miller School of Medicine, University of Miami, Miami, Florida, USA. jgoldberg2@med.miami.edu

Current Opinion in Oncology

|June 6, 2013

Summary

Immunotherapy represents a promising new treatment for sarcoma, a connective tissue cancer. Advances in cancer immunotherapy suggest its potential integration with existing therapies for improved outcomes.

Area of Science:

Oncology
Immunology
Cancer Research

Background:

Sarcoma is a connective tissue cancer affecting all age groups, with a notable prevalence in younger individuals.
While molecularly targeted inhibitors are explored, immunotherapy is gaining traction as a viable therapeutic option for sarcoma.
Recent successes in other cancer types and specific immunotherapies (e.g., ipilimumab, sipuleucel-T) highlight its potential applicability to sarcoma.

Purpose of the Study:

To review current advancements in immunotherapy relevant to sarcoma treatment.
To explore the potential application of immunotherapy, alone or in combination, for managing sarcoma.
To discuss recent literature and clinical trials concerning immunotherapy in sarcoma.

Main Methods:

Literature review of recent scientific publications.

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Analysis of selected clinical trials on immunotherapy for sarcoma.

Synthesis of evidence supporting immunotherapy in sarcoma treatment.

Main Results:

Immunotherapy is emerging as a plausible therapeutic modality for sarcoma.
The success of immunotherapy in other cancers suggests translatability to sarcoma.
Approved immunotherapies and their efficacy in pediatric cancers support exploring their role in sarcoma.

Conclusions:

New treatment strategies are urgently needed for sarcoma.
Immunotherapies offer novel mechanisms of action that can complement existing treatments.
Advances in sarcoma biology and cancer immunotherapy enable the augmentation of targeted and multimodality therapy for sarcoma.