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Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Tubercular retinal vasculitis.

Maria Sara Patricio¹, Joana Portelinha, Maria Picoto Passarinho

¹Department of Ophthalmology, Hospital de Egas Moniz, Lisbon, Portugal. msarapatricio@gmail.com

BMJ Case Reports

|June 6, 2013

Summary

Intraocular tuberculosis (TB) can cause retinal vasculitis and vision loss. Early diagnosis and antituberculosis treatment (ATT) significantly improved vision and prevented recurrences in a patient with Eales Disease.

Area of Science:

Ophthalmology
Infectious Diseases
Medical Microbiology

Background:

Intraocular tuberculosis (TB) presents varied clinical manifestations, notably retinal vasculitis, often affecting veins and leading to hemorrhages and neovascularization.
Diagnosis can be challenging, relying on clinical signs and systemic TB evidence.

Observation:

A 61-year-old woman experienced 6 years of blurred vision and floaters, diagnosed initially as retinal vein occlusion.
Bilateral venous occlusion and vasculitis suggestive of Eales Disease were observed.
Interferon gamma release assay (IGRA-QuantiFERON-TB Gold) confirmed TB infection.

Findings:

Antituberculosis treatment (ATT) was initiated.
The patient's best-corrected visual acuity improved from 20/50 to 20/20 bilaterally.

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No recurrences were noted during a 15-month follow-up period.

Implications:

Antituberculosis treatment (ATT) effectively manages intraocular tuberculosis presenting as Eales Disease.
ATT can prevent recurrent vitreous hemorrhages and improve visual outcomes in affected individuals.