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Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
GPCR Desensitization01:12

GPCR Desensitization

G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...

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Related Experiment Video

Updated: May 10, 2026

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions
12:30

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Published on: March 5, 2012

Recent advances in DENV receptors.

Shuyu Fang1, Yanhua Wu, Na Wu

  • 1Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.

Thescientificworldjournal
|June 6, 2013
PubMed
Summary

Dengue viruses (DENVs) bind to host cells via various receptors, crucial for infection and disease severity. This review summarizes recent findings on DENV receptors on target cells like dendritic cells and macrophages.

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Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
11:49

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

Published on: July 28, 2014

Related Experiment Videos

Last Updated: May 10, 2026

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions
12:30

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Published on: March 5, 2012

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

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Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
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Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

Published on: July 28, 2014

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Dengue is a mosquito-borne viral disease caused by four dengue virus serotypes (DENV1-4).
  • Dengue incidence has surged globally, posing a significant public health risk.
  • The precise mechanisms of dengue pathogenesis, particularly viral entry, remain incompletely understood.

Purpose of the Study:

  • To review and summarize recently identified receptors for dengue viruses (DENVs) on various host cells.
  • To highlight the critical role of virus-host cell interactions in dengue virus replication and pathogenicity.

Main Methods:

  • Literature review of recent research on dengue virus-host cell interactions.
  • Compilation of identified DENV receptors on target cells, including dendritic cells, macrophages, endothelial cells, and hepatocytes.

Main Results:

  • Dengue viruses attach to a diverse range of receptors on susceptible host cells.
  • Specific receptors have been identified on key target cells, although a universal DENV receptor is yet to be defined.
  • Understanding these interactions is vital for elucidating dengue pathogenesis.

Conclusions:

  • The interaction between dengue viruses and host cell receptors is a critical determinant of infection and disease.
  • Continued research into DENV receptors is essential for developing effective antiviral strategies and understanding disease progression.