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Updated: May 10, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53 codon 72 polymorphism and breast cancer risk: A meta-analysis
Jing Hou1, Yuan Jiang, Wenru Tang
1Laboratory of Molecular Genetics of Aging and Tumor, Medical Faculty;
Experimental and Therapeutic Medicine
|June 6, 2013
Summary
The p53 codon 72 polymorphism does not appear to increase breast cancer risk. This meta-analysis found no significant association between variant genotypes and overall breast cancer risk in the evaluated populations.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The p53 gene is a crucial tumor suppressor involved in breast cancer development.
- Conflicting findings exist regarding the association between the p53 codon 72 polymorphism (G>C) and breast cancer risk.
Purpose of the Study:
- To conduct a meta-analysis to definitively assess the relationship between the p53 codon 72 polymorphism and breast cancer risk.
- To consolidate evidence from existing studies to provide a more robust estimate of the association.
Main Methods:
- A systematic literature search was performed on the PubMed database.
- Sixty-one studies comprising 28,539 breast cancer cases and 32,788 controls were included.
- Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association, and publication bias was evaluated using funnel plots and Egger's/Begg's tests.
Main Results:
- The meta-analysis revealed no statistically significant association between variant p53 codon 72 genotypes (Pro/Pro + Arg/Pro) and breast cancer risk when compared to the Arg/Arg genotype (OR=1.016, 95% CI=0.931-1.11, P=0.722).
- Publication bias was assessed and found to be minimal, indicated by a symmetric funnel plot and non-significant Egger's (P=0.506) and Begg's (P=0.921) tests.
- The results indicate that common genotypes of the p53 codon 72 polymorphism do not confer an increased susceptibility to breast cancer.
Conclusions:
- This comprehensive meta-analysis suggests that the p53 codon 72 polymorphism does not significantly alter the risk of developing breast cancer.
- Further large-scale, global studies are warranted to confirm these findings and explore potential subtle associations or interactions.
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