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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
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Association between plasma soluble P-selectin elements and progressive ischemic stroke.

Qian Wang1, Weili Zhao, Shufeng Bai

  • 1Department of Emergency, General Hospital of Chinese People's Armed Police Forces, Beijing 100039;

Experimental and Therapeutic Medicine
|June 6, 2013
PubMed
Summary

Plasma-soluble P-selectin (sP-selectin) levels are elevated in patients with progressive ischemic stroke (PIS). Higher sP-selectin levels correlate with stroke progression and onset time, offering insights into PIS pathogenesis.

Keywords:
P-selectinprogressive cerebral infarctionrisk factors

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Area of Science:

  • Neurology
  • Biochemistry
  • Cardiovascular Research

Background:

  • Progressive ischemic stroke (PIS) pathogenesis remains incompletely understood.
  • Soluble P-selectin (sP-selectin) is a marker of endothelial activation and platelet aggregation.
  • Investigating sP-selectin's role may elucidate mechanisms underlying stroke progression.

Purpose of the Study:

  • To analyze the association between plasma-soluble P-selectin (sP-selectin) and progressive ischemic stroke (PIS).
  • To explore the underlying pathogenesis of PIS.
  • To compare sP-selectin levels in progressive vs. non-progressive stroke patients and controls.

Main Methods:

  • Prospective study of acute ischemic stroke patients hospitalized between August 2010 and August 2011.
  • Patients categorized into progressive (58), non-progressive (143), and control (40) groups.
  • Plasma sP-selectin levels measured on days 1, 3, 7, and 14 post-admission; risk factors also assessed.

Main Results:

  • sP-selectin levels were significantly higher in the progressive stroke group compared to non-progressive and control groups on day 1 (P<0.05).
  • Elevated sP-selectin persisted in the progressive group on days 3 and 7 (P<0.05), and remained higher on day 14 (P>0.05).
  • Patients with progressive aortic atherosclerosis also showed higher sP-selectin levels.

Conclusions:

  • Plasma sP-selectin is a significant biomarker associated with progressive ischemic stroke.
  • Elevated sP-selectin levels correlate with stroke progression and potentially with aortic atherosclerosis progression.
  • sP-selectin may play a crucial role in the pathogenesis of PIS.