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Correlation between plasma lipoprotein-associated phospholipase A2 and peripheral arterial disease
Shuai-Bing Li1, Fan Yang, Li Jing
1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, P.R. China.
Experimental and Therapeutic Medicine
|June 6, 2013
Summary
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is independently linked to peripheral arterial disease (PAD). This study highlights Lp-PLA2 as a potential biomarker for atherosclerosis in PAD patients.
Area of Science:
- Cardiovascular Medicine
- Biomarker Discovery
- Atherosclerosis Research
Background:
- Peripheral arterial disease (PAD) is a significant manifestation of atherosclerosis.
- The role of lipoprotein-associated phospholipase A2 (Lp-PLA2) in PAD pathogenesis is not well-established.
- Ankle-brachial blood pressure index (ABI) is a key indicator for diagnosing PAD.
Purpose of the Study:
- To investigate the independent association between Lp-PLA2 levels and PAD.
- To evaluate Lp-PLA2 alongside other inflammatory markers in relation to reduced ABI.
- To determine if Lp-PLA2 serves as a distinct biomarker for PAD.
Main Methods:
- Cross-sectional study involving 982 individuals aged 40 years and above.
- PAD defined as ABI <0.9 in at least one leg.
- Statistical analysis adjusted for traditional cardiovascular risk factors, comparing Lp-PLA2 quartiles and assessing multiple inflammatory markers.
Main Results:
- Elevated Lp-PLA2 levels were significantly associated with PAD (OR 3.24 in highest vs. lowest quartile after initial adjustment).
- After adjusting for other inflammatory markers, Lp-PLA2 remained independently associated with PAD (OR 1.81).
- Other markers like homocysteine, fibrinogen, and apolipoprotein B also showed associations, but Lp-PLA2 demonstrated independent predictive value.
Conclusions:
- Circulating Lp-PLA2 levels are significantly and independently associated with PAD.
- Lp-PLA2 may serve as a valuable plasma biomarker for identifying individuals with PAD.
- These findings support the role of Lp-PLA2 in the atherosclerotic process affecting peripheral arteries.
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