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Updated: May 10, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Glucanase induces filamentation of the fungal pathogen Candida albicans
Hongbin Xu1, Clarissa J Nobile, Anna Dongari-Bagtzoglou
1Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, Connecticut, USA. hxu@uchc.edu
Abstract:
Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans, secrete glucanases under different environmental conditions. Here, we report a novel role for beta-1, 3- glucanase in inducing Candida albicans to form filaments at 22°C and enhancing filamentation at 37°C in nutrient-rich medium. Quorum sensing, the efg1-signaling and cek1 MAP kinase pathways are involved in this process. Our data suggest that the natural antifungal agent beta-glucanase may support morphologic transformation of Candida albicans at a wide range of ambient temperatures.
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