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Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice

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Persistent HyperCKemia in Athletes.

Paola Brancaccio¹, Nicola Maffulli, Luisa Politano

¹Seconda Università di Napoli, Servizio di Medicina dello Sport, Department of Experimental Medicine, Centre of Excellence of Cardiovascular Disease, Napoli, Italy (PB, GL, FML).

Muscles, Ligaments and Tendons Journal

|June 6, 2013

Summary

This summary is machine-generated.

Athletes with high resting creatine kinase (CK) levels show prolonged elevated CK post-exercise compared to healthy athletes. This indicates different exercise responses in athletes with persistent hyperCKemia.

Keywords:

Hyperckemia Muscular Enzymes Primitive Myopathy

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Area of Science:

Exercise Physiology
Biochemistry
Sports Medicine

Background:

Persistent hyperCKemia, defined as high resting serum creatine kinase (CK) levels, is observed in some athletes.
The impact of exercise on serum CK levels in athletes with pre-existing hyperCKemia is not fully understood.

Purpose of the Study:

To compare the effects of exercise on serum CK levels in athletes with persistent hyperCKemia versus healthy athletes.
To investigate the kinetics of serum CK levels following exhaustive exercise in these two groups.

Main Methods:

A prospective controlled study involving 18 male athletes with high resting CK (CK group) and 25 healthy male athletes (control group).
Blood samples were collected at rest and at multiple time points (30 min, 6, 24, 48, 72 hours) after a progressive cycloergometer test to exhaustion.
Serum CK and isoenzyme levels were measured.

Main Results:

Control group athletes had normal resting CK levels that slightly increased post-exercise, returning to baseline within 48 hours.
CK group athletes exhibited significantly higher resting CK levels, which remained elevated above the normal range for at least 72 hours post-exercise.
Significant differences in serum CK levels and post-exercise kinetics were observed between the two groups.

Conclusions:

Athletes with persistent hyperCKemia demonstrate altered serum CK responses to exercise compared to healthy athletes.
Elevated serum CK levels in this group persist longer after exertion, suggesting a different physiological response to physical stress.