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Related Experiment Video

Updated: May 10, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

Oxidative system in aged skeletal muscle.

Daniela Buonocore¹, Sara Rucci, Matteo Vandoni

¹Laboratory of Pharmaco-biochemistry, Nutrition and Nutraceutics of Wellness, University of Pavia, Italy.

Muscles, Ligaments and Tendons Journal

|June 6, 2013

Summary

Aging human skeletal muscles experience increased oxidative stress due to declining mitochondrial function and reduced antioxidant defenses. This review examines how factors like sex and muscle type influence this age-related decline.

Keywords:

ROS aged skeletal muscle markers of skeletal muscle aging oxidative system sarcopenia

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Last Updated: May 10, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry

Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry

Published on: October 4, 2024

Area of Science:

Gerontology
Skeletal Muscle Physiology
Cellular Biology

Background:

Aging leads to a decline in physiological functions, particularly in the neuromuscular system, causing reduced strength and mobility.
Cellular aging is linked to decreased mitochondrial function and increased reactive oxygen species (ROS) production.
Oxidative stress in skeletal muscle rises with age, creating an imbalance between ROS generation and antioxidant defenses.

Purpose of the Study:

To review existing literature on oxidative stress in aging human skeletal muscles.
To assess the impact of physiological factors on oxidative stress in aging muscles.

Main Methods:

Literature review of studies on aging, skeletal muscle, and oxidative stress.
Analysis of physiological factors including sex, muscle fiber composition, muscle type, and function.

Main Results:

Aging skeletal muscle exhibits increased oxidative stress.
Physiological variations influence the extent of oxidative stress and its impact on muscle function.

Conclusions:

Oxidative stress is a key factor in age-related skeletal muscle decline.
Understanding physiological differences is crucial for addressing muscle aging and maintaining function.