Proteomic profiling of skeletal muscle plasticity

Area of Science:

• Biochemistry
• Physiology
• Molecular Biology

Background:

• Skeletal muscle exhibits remarkable plasticity, adapting to diverse functional demands.
• Traditional methods have extensively studied muscle plasticity; recent advances include high-throughput proteomic techniques.
• Proteomics offers a global view of the skeletal muscle protein complement during physiological and pathophysiological changes.

Purpose of the Study:

• To review and discuss recent proteomic profiling studies of skeletal muscle transitions.
• To examine the impact of various stimuli on the skeletal muscle proteome.
• To critically evaluate the biomedical importance of biomarker signatures in muscle transformation.

Main Methods:

• Mass spectrometry-based proteomic surveys.
• Global analysis of skeletal muscle protein complement.
• Review of studies on human and animal models of muscle plasticity and neuromuscular pathologies.

Main Results:

• Proteomic profiling has been applied to diverse skeletal muscle transitions.
• Studies cover effects of chronic electro-stimulation, exercise, denervation, disuse atrophy, hypoxia, myotonia, motor neuron disease, and age-related changes.
• Human and animal models provide insights into muscle plasticity and disease.

Conclusions:

• Proteomic approaches are crucial for understanding skeletal muscle adaptation.
• Identifying reliable biomarker signatures is vital for diagnosing and managing muscle disorders.
• Further research can leverage proteomic data for therapeutic strategies in muscle transformation.