Related Experiment Video

Updated: May 10, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Mesenchymal stem cells, aging and regenerative medicine

Chiara Raggi1, Anna C Berardi

  • 1Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, USA.

Muscles, Ligaments and Tendons Journal
|June 6, 2013
PubMed

Insights

Stem cell aging impacts tissue repair. This review examines how age affects mesenchymal stromal cells (MSCs), crucial for regeneration, and their therapeutic potential.

Area of Science:

  • Stem cell biology
  • Gerontology
  • Regenerative medicine

Background:

  • Tissue maintenance and regeneration rely on stem cells.
  • Stem cell function declines with increasing age.
  • Age-related stem cell decline may affect therapeutic outcomes.

Purpose of the Study:

  • To discuss the impact of aging on mesenchymal stromal cells (MSCs).
  • To consider the implications of age-related changes in MSCs for research and regenerative medicine.

Main Methods:

  • Literature review and synthesis of existing research on MSC aging.
  • Analysis of age-associated alterations in MSC properties.
  • Discussion of the functional consequences of MSC aging.

Main Results:

  • Mesenchymal stromal cells (MSCs) exhibit age-related changes affecting their properties.
  • These changes can influence the efficacy of MSC-based therapies.
  • Understanding these alterations is critical for optimizing regenerative medicine strategies.

Conclusions:

  • Age-related decline in stem cell function, particularly MSCs, presents challenges for regenerative medicine.
  • Further research is needed to address the effects of aging on MSCs for therapeutic applications.
Keywords:
agingmesenchymal stem cells (MSCs)regenerative medicinestem cells

More Related Videos

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta07:06

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta

Published on: April 3, 2017

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...